Key result
In hemodialysis patients, vitamin K antagonists are associated with nontraditional side effects including the induction or acceleration of cardiovascular calcifications and a 10-fold increased risk of calciphylaxis.
Why the study?
What are the non-traditional side effects and risks of vitamin K antagonists in hemodialysis patients?
What are the non-traditional side effects and risks of vitamin K antagonists in hemodialysis patients?
In hemodialysis patients, the prescription of vitamin K antagonists requires careful consideration of non-traditional side effects such as cardiovascular calcification and calciphylaxis, which may outweigh assumed benefits.
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Urges caution prescribing vitamin K antagonists in hemodialysis; leaves open whether alternatives reduce calcification and calciphylaxis risks.
Krüger et al. (2014) conducted a review in End-stage renal disease (ESRD) / Hemodialysis requiring anticoagulation. Vitamin K Antagonists (Warfarin / Coumarins) was evaluated. In hemodialysis patients, vitamin K antagonists are associated with nontraditional side effects including the induction or acceleration of cardiovascular calcifications and a 10-fold increased risk of calciphylaxis.
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