Key result
Nephrotic syndrome was associated with significantly higher serum lipoprotein(a) levels compared to healthy controls (30.4 vs 10.4 mg/dl).
Why the study?
Are serum Lp(a) levels elevated in patients with nephrotic syndrome compared to healthy controls?
Population
20 patients with nephrotic syndrome and 32 healthy controls.
Design
Case-control
Authors
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May link Lp(a) elevation to thrombotic risk in nephrotic syndrome; hypothesis-generating pending prospective outcome trials.
Case-Control (n=52)
No
Are serum Lp(a) levels elevated in patients with nephrotic syndrome compared to healthy controls?
Absolute Event Rate: 30.4% vs 10.4%
p-value: p=<0.05
Serum Lp(a) levels are significantly elevated in patients with nephrotic syndrome, likely due to increased hepatic synthesis secondary to hypoalbuminemia, which may contribute to their increased risk of thrombotic complications.
Kanno et al. (1992) conducted a case-control in Nephrotic syndrome (n=52). Nephrotic syndrome vs. Healthy controls was evaluated on Serum Lipoprotein(a) levels (mg/dl) (p=<0.05). Nephrotic syndrome was associated with significantly higher serum lipoprotein(a) levels compared to healthy controls (30.4 vs 10.4 mg/dl).
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