Key result
Prolonged anovulation decreases insulin sensitivity, while improving insulin sensitivity normalizes ovarian function in polycystic ovary syndrome.
Why the study?
Does improving insulin sensitivity with metformin or troglitazone normalize ovarian function in patients with polycystic ovary syndrome?
Does improving insulin sensitivity with metformin or troglitazone normalize ovarian function in patients with polycystic ovary syndrome?
Improving insulin sensitivity with agents like metformin and troglitazone may help normalize ovarian function in patients with polycystic ovary syndrome.
Answers are grounded in this paper and cite their sources.
May support targeting insulin sensitivity to restore ovulation in PCOS; hypothesis-generating and requires prospective RCTs before practice change.
This review sets in context significant recent advances in the understanding of the pathophysiology of polycystic ovary syndrome (PCOS). The occurrence of variable insulin sensitivity in individuals is discussed. Information is presented to demonstrate that prolonged anovulation decreases insulin sensitivity and, conversely, that improvement in insulin sensitivity normalizes ovarian function in PCOS. In addition, a meta-analysis of studies on metformin and troglitazone treatment in PCOS is presented.
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Taylor et al. (2000) conducted a review in Polycystic ovary syndrome (PCOS). Metformin and troglitazone was evaluated. Prolonged anovulation decreases insulin sensitivity, while improving insulin sensitivity normalizes ovarian function in polycystic ovary syndrome.
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