Key result
Thiazolidinediones increase ovulation rates and successful pregnancies in patients with polycystic ovary syndrome by decreasing peripheral insulin resistance and acting at the ovarian level.
Why the study?
Do insulin sensitizers (metformin or thiazolidinediones) improve ovulation rate and successful pregnancies in patients with Polycystic ovary syndrome (PCOS)?
Do insulin sensitizers (metformin or thiazolidinediones) improve ovulation rate and successful pregnancies in patients with Polycystic ovary syndrome (PCOS)?
Insulin sensitizers such as thiazolidinediones may improve fertility in PCOS patients through both decreased peripheral insulin resistance and direct ovarian action.
May support direct ovarian TZD actions in PCOS; leaves open clinical relevance beyond insulin sensitization.
Polycystic ovary syndrome (PCOS) is the most frequent cause of female infertility. The treatment of PCOS patients with insulin sensitizers, such as metformin or thiazolidinediones, increases the ovulation rate and the number of successful pregnancies. The positive action of the insulin-sensitizing treatments could be explained by a decrease in the peripheral insulin resistance but also by a direct action at the ovarian level. We report in this review different hypotheses of thiazolidinediones actions to improve PCOS (steroid secretion by ovarian cells ; insulin sensitivity in muscle and adipocyte and fat redistribution).
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Froment et al. (2006) conducted a review in Polycystic Ovary Syndrome (PCOS). Thiazolidinediones was evaluated. Thiazolidinediones increase ovulation rates and successful pregnancies in patients with polycystic ovary syndrome by decreasing peripheral insulin resistance and acting at the ovarian level.
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