Key result
Antihypertensive drug consumption in Spain increased by 117.4% between 1986 and 1994, with significant increases in the use of ACE inhibitors, calcium antagonists, and beta-blockers.
Observational
Antihypertensive drug consumption in Spain more than doubled between 1986 and 1994, with a rapid rise in newer agents like ACE inhibitors and calcium antagonists, though diuretics remained the most prescribed.
Answers are grounded in this paper and cite their sources.
Documents evolving antihypertensive prescribing patterns; extends historical data but leaves open relevance to contemporary control and outcomes.
We aimed to analyze the trends in antihypertensive therapy in Spain during the period 1986 to 1994, as well as the change in the pattern of different drugs, in relation to different national/international recommendations for hypertension treatment. Antihypertensive consumption was studied using the defined daily dose (DDD) and the DHD (DDD/1000 inhabitants/day) of each drug, as defined by the Drug Utilization Research Group of the European Office of the World Health Organization. The anatomical classification of hypotensive drugs has been made according to EPhMRA (European Pharmaceutical Market Association) guidelines. A significant increase of 117.4% (41.39/90 DHD) in antihypertensive drug consumption was observed in the period 1986 to 1994. In 1986 diuretics were the most consumed (30.27 DHD), followed by calcium antagonists (5.37), beta-blockers (3.93), and the angiotensin-converting enzyme (ACE) inhibitor (1.37). In 1994 ACE inhibitors, calcium antagonists, and beta-blockers increased significantly (P < .0001), whereas diuretics were still the most commonly prescribed. Nifedipine and captopril were the most used among calcium antagonists and ACE inhibitors. National and international recommendations had no effect on prescription patterns. Antihypertensive therapy of all types is increasing in Spain. Diuretics remain the most popular, beta-blockers stay stable, whereas the newer types are rising rapidly. National and international recommendations had no effect on prescription patterns.
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Jabary et al. (2000) conducted an observational in Hypertension. Antihypertensive therapy vs. 1986 baseline was evaluated on Antihypertensive drug consumption (DHD) (117.4% increase). Antihypertensive drug consumption in Spain increased by 117.4% between 1986 and 1994, with significant increases in the use of ACE inhibitors, calcium antagonists, and beta-blockers.
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