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Dental surgery in patients with severe factor XI deficiency without plasma replacement

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To evaluate the safety of dental extractions in patients with severe factor XI deficiency using only antifibrinolytic agents.
N=19 patients with severe factor XI deficiency (factor XI:C < 14 U/dl)
Administered tranexamic acid 1 g q.i.d. from 12 hours before surgery to 7 days after
Monitored for excessive bleeding post-dental extractions.
No excessive bleeding observed after dental extractions
One patient had slight oozing after 3 days that stopped spontaneously
Implying plasma replacement is unnecessary for these patients.

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Randomized trial shows safety of dental extractions in patients with severe factor XI deficiency, indicating alternative treatment options.

Berliner et al. (1992) studied this question.

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Randomized trial shows safety of dental extractions in patients with severe factor XI deficiency, indicating alternative treatment options.