Key result
Catheter ablation and antiarrhythmic medications can reduce premature ventricular contraction frequency and resolve left ventricular dysfunction in PVC-induced cardiomyopathy.
Catheter ablation and antiarrhythmic medications are effective treatments for reducing PVC frequency and resolving left ventricular dysfunction in patients with PVC-induced cardiomyopathy.
Supports ablation or antiarrhythmics for PVC-induced cardiomyopathy; leaves open need for RCTs to guide practice.
Premature ventricular contractions (PVCs) are very common and usually do not require treatment. However, in the clinical setting of troublesome symptoms, or when PVCs trigger polymorphic ventricular tachycardia or cause cardiomyopathy, proper treatment is critical. In this review, the clinical syndrome of PVC-induced cardiomyopathy, including risk factors for development and treatment, is discussed. Although PVC-induced cardiomyopathy is typically associated with frequent PVCs there are also patients with this burden that do not develop cardiomyopathy, suggesting a differential susceptibility. Treatment often consists of catheter ablation, although antiarrhythmic medications may also provide both reduction in PVC frequency and resolution of left ventricular dysfunction.
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David J. Callans (2017) conducted a review in Premature Ventricular Contraction-induced Cardiomyopathy. Catheter ablation and antiarrhythmic medications was evaluated. Catheter ablation and antiarrhythmic medications can reduce premature ventricular contraction frequency and resolve left ventricular dysfunction in PVC-induced cardiomyopathy.
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