Answers are grounded in this paper and cite their sources.
The predominant mechanism for resistance to β-lactam antibiotics in gram-negative bacteria is the synthesis of β-lactamase. To meet this challenge, β-lactams with greater β-lactamase stability, including cephalosporins, carbapenems, and monobactams, were introduced in the 1980s. Resistance
No takes yet. Share an insight, caveat, or question.
Philippon et al. (2002) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: