Key result
Coronary artery occlusion elicited a significantly greater heart rate increase (176.4 vs 145.7 beats/min) and greater reduction in cardiac vagal tone in dogs susceptible to ventricular fibrillation.
Why the study?
Does acute coronary occlusion elicit different autonomic responses in dogs susceptible versus resistant to ventricular fibrillation?
Does acute coronary occlusion elicit different autonomic responses in dogs susceptible versus resistant to ventricular fibrillation?
Absolute Event Rate: 176.4% vs 145.7%
Coronary artery occlusion elicits a significantly greater increase in sympathetic activity and reduction in parasympathetic activity in animals susceptible to ventricular fibrillation.
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Autonomic imbalance during ischemia may heighten VF susceptibility; hypothesis-generating in animals, leaves open human translation.
Collins et al. (1989) studied Healed myocardial infarction (n=29). Susceptibility to ventricular fibrillation vs. Resistance to ventricular fibrillation was evaluated on Heart rate during coronary occlusion (beats/min). Coronary artery occlusion elicited a significantly greater heart rate increase (176.4 vs 145.7 beats/min) and greater reduction in cardiac vagal tone in dogs susceptible to ventricular fibrillation.
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