Key result
Atropine injection before coronary artery occlusion in dogs with healed myocardial infarction induced ventricular fibrillation in 24% of previously resistant animals (P=0.001).
Why the study?
Does vagal blockade with atropine increase the risk of ventricular fibrillation during acute myocardial ischemia in dogs with healed myocardial infarction?
Does vagal blockade with atropine increase the risk of ventricular fibrillation during acute myocardial ischemia in dogs with healed myocardial infarction?
Absolute Event Rate: 24% vs 0%
p-value: p=0.001
In a canine model of healed myocardial infarction, powerful vagal reflexes that decrease heart rate during acute ischemia are essential for survival and prevention of ventricular fibrillation in a subset of animals.
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Vagal blockade may heighten ventricular fibrillation risk during ischemia; leaves open translation to human post-MI arrhythmia prevention.
Ferrari et al. (1991) studied Healed anterior myocardial infarction (animal model) (n=45). Atropine injection before coronary artery occlusion vs. Control test (exercise and ischemia without atropine) was evaluated on Ventricular fibrillation (p=0.001). Atropine injection before coronary artery occlusion in dogs with healed myocardial infarction induced ventricular fibrillation in 24% of previously resistant animals (P=0.001).
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