Why the study?
Do atropine, atrial pacing, or lidocaine suppress ventricular arrhythmias in a canine model of acute myocardial infarction?
Population
72 closed-chest conscious dogs with acute myocardial infarction produced by inflating a balloon cuff…
Design
Preclinical
Follow-up
Acute phase (during occlusion or within 2 min of release)
Authors
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Suppresses benign but not malignant arrhythmias in canine AMI; leaves open clinical relevance for VF prevention.
Do atropine, atrial pacing, or lidocaine suppress ventricular arrhythmias in a canine model of acute myocardial infarction?
In a canine model of acute myocardial infarction, atropine, pacing, and lidocaine effectively suppressed benign ventricular arrhythmias but were largely ineffective against malignant arrhythmias that frequently lead to ventricular fibrillation.
Epstein et al. (1973) studied this question.
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