Key result
Normotensive OSAS was associated with lower serum fetuin-A levels (59.4 vs 68.2 ng/mL, P=0.029), higher mean cIMT, and greater carotid stiffness compared to non-OSAS controls.
Why the study?
Are serum fetuin-A levels associated with carotid artery stiffness and intima-media thickness in patients with normotensive obstructive sleep apnea syndrome?
Case-Control (n=88)
Are serum fetuin-A levels associated with carotid artery stiffness and intima-media thickness in patients with normotensive obstructive sleep apnea syndrome?
Absolute Event Rate: 59.4% vs 68.2%
p-value: p=0.029
Decreased serum fetuin-A levels are associated with subclinical carotid atherosclerosis, reflected by increased cIMT and stiffness, in patients with normotensive OSAS.
Supports fetuin-A as potential biomarker for carotid changes in normotensive OSAS; hypothesis-generating and should not yet change practice.
Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 ± 6.5 vs 68.2 ± 5.8 ng/mL, P = .029), higher mean cIMT (0.73 ± 0.2 vs 0.63 ± 0.3 mm, P < .001), and greater stiffness (β) index (7.45 ± 0.9 vs 5.2 ± 0.7, P = .001) in the OSAS group. The cIMT and stiffness (β) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS.
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Akyüz et al. (2013) conducted a case-control in Normotensive obstructive sleep apnea syndrome (n=88). Normotensive obstructive sleep apnea syndrome vs. Non-OSAS controls was evaluated on Serum fetuin-A levels (ng/mL) (p=0.029). Normotensive OSAS was associated with lower serum fetuin-A levels (59.4 vs 68.2 ng/mL, P=0.029), higher mean cIMT, and greater carotid stiffness compared to non-OSAS controls.
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