Why the study?
Does Midodrine reduce the recurrence of syncope and pre-syncope in patients with recurrent vasovagal syncope not responding to non-pharmacological treatment?
Does Midodrine reduce the recurrence of syncope and pre-syncope in patients with recurrent vasovagal syncope not responding to non-pharmacological treatment?
Midodrine did not significantly reduce the recurrence of syncope or pre-syncope compared to placebo in patients with vasovagal syncope refractory to non-pharmacological treatment.
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Midodrine shows no benefit over placebo for refractory vasovagal syncope; challenges its use and prior nonrandomized assumptions.
Romme et al. (2011) studied this question.
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