Non-pharmacological treatment significantly reduced the median number of syncopal recurrences compared to the prior year (0 vs. 3; P<0.001), although 49% of patients still experienced a recurrence.
Observational (n=100)
Open-label
Does non-pharmacological treatment reduce syncopal recurrences and improve quality of life in patients with frequent vasovagal syncope?
Non-pharmacological treatment significantly reduces syncope burden and improves quality of life in patients with frequent vasovagal syncope, although recurrences remain common.
Absolute Event Rate: 0% vs 3%
p-value: p=<0.001
AIMS: Initial treatment of vasovagal syncope (VVS) consists of assuring an adequate fluid and salt intake, regular exercise and application of physical counterpressure manoeuvres. We examined the effects of this non-pharmacological treatment in patients with frequent recurrences. METHODS AND RESULTS: One hundred patients with > or =3 episodes of VVS in the 2 years prior to the start of the study openly received non-pharmacological treatment. We evaluated this treatment both with respect to syncopal recurrences, factors associated with recurrence, and quality of life (QoL). The median number of syncopal recurrences was lower in the first year of non-pharmacological treatment compared with the last year before treatment (median 0 vs. 3; P < 0.001), but 49% of patients experienced at least one recurrence. In multivariable analysis, a higher syncope burden prior to inclusion was significantly associated with syncopal recurrence. Disease-specific QoL improved over time, with larger improvements for patients with more reduction in syncope burden. CONCLUSION: In patients with frequent recurrences of VVS, non-pharmacological treatment has a beneficial effect on both syncopal recurrence and QoL, but nearly half of these patients still experience episodes of syncope.
Romme et al. (Sun,) conducted a observational in Vasovagal syncope (n=100). Non-pharmacological treatment (fluid/salt intake, exercise, physical counterpressure) vs. Last year before treatment (historical control) was evaluated on Median number of syncopal recurrences (p=<0.001). Non-pharmacological treatment significantly reduced the median number of syncopal recurrences compared to the prior year (0 vs. 3; P<0.001), although 49% of patients still experienced a recurrence.