Population
Sindbis virus infected and uninfected cells
Comparison
Chimeric mRNAs containing the first 275… vs Viral RNA lacking the hairpin-like structure
Design
Preclinical
Authors
Loading...
Hypothesis-generating for alphavirus vector engineering; leaves open validation in other viral systems or mammalian hosts.
A hairpin-like structure downstream of the initiating codon in Sindbis virus mRNA enhances translation in infected cells by slowing ribosome transit, allowing low-concentration factors to bind.
Frolov et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: