Population
BHK cells infected with defective-interfering passages of Sindbis virus
Comparison
Defective-interfering passages of Sindbis virus vs Standard passages of Sindbis virus
Design
Preclinical
Authors
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Non-functional 20S RNA in Sindbis defective particles informs interference models; leaves open in vivo validation and therapeutic translation.
Defective interfering passages of Sindbis virus produce a 20S RNA that lacks messenger function and cannot synthesize a functional replicase.
Weiss et al. (1974) studied this question.
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