Key result
Oral contraceptives were associated with an approximately two-fold increase in risk of death from myocardial infarction, apparent only in women with no known risk factors for ischaemic heart disease.
Why the study?
Does oral contraceptive use increase the risk of death from myocardial infarction in women aged 15-44 years?
Population
Women aged 15-44 years in England and Wales
Comparison
Oral contraceptives vs Non-use of oral contraceptives
Design
Case-control
Authors
Loading...
May warrant caution prescribing oral contraceptives to low-risk women; leaves open effects of modern formulations.
Case-Control
Yes
Does oral contraceptive use increase the risk of death from myocardial infarction in women aged 15-44 years?
Effect estimate: approximately two-fold increase in risk
Oral contraceptives are associated with a two-fold increased risk of fatal myocardial infarction in young women without known ischemic heart disease risk factors, regardless of estrogen dose (≤30 vs 50 mcg).
Adam et al. (1981) conducted a case-control in Myocardial infarction. Oral contraceptives vs. No oral contraceptive use was evaluated on Death from myocardial infarction (approximately two-fold increase in risk). Oral contraceptives were associated with an approximately two-fold increase in risk of death from myocardial infarction, apparent only in women with no known risk factors for ischaemic heart disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: