Key result
AF is linked to ~31% lower right atrial Kv1.5 protein expression vs sinus rhythm.
Why the study?
Does atrial fibrillation alter the expression of Kv1.5 channels in the right atria of Han Chinese patients compared to sinus rhythm?
Cross-Sectional (n=46)
No
Does atrial fibrillation alter the expression of Kv1.5 channels in the right atria of Han Chinese patients compared to sinus rhythm?
The downregulation of right atrial Kv1.5 protein expression is associated with atrial fibrillation independently of age, sex, or rheumatic heart disease, supporting the role of ion-channel remodeling in AF pathophysiology.
Answers are grounded in this paper and cite their sources.
Does not alter AF management; extends remodeling observations but leaves open causality and therapeutic relevance.
BACKGROUND: The incidence of atrial fibrillation (AF) in rheumatic heart diseases (RHD) is very high and increases with age. Occurrence and maintenance of AF are very complicated process accompanied by many different mechanisms. Ion-channel remodeling, including the voltage-gated potassium channel Kv1.5, plays an important role in the pathophysiology of AF. However, the changes of Kv1.5 channel expression in Han Chinese patients with RHD and AF remain poorly understood. The aim of the present study was to investigate whether the Kv1.5 channels of the right atria may be altered with RHD, age, and sex to contribute to AF. MATERIAL/METHODS: Right atrial appendages were obtained from 20 patients with normal cardiac functions who had undergone surgery, and 26 patients with AF. Subjects were picked from 4 groups: adult and aged patients in normal sinus rhythm (SR) and AF. Patients were divided into non-RHD and RHD groups or men and women groups in normal SR and AF, respectively. The expression of Kv1.5 protein and messenger RNA (mRNA) were measured using Western blotting and polymerase chain reaction (PCR) method, respectively. RESULTS: Compared with the SR group, the expression of Kv1.5 protein decreased significantly in the AF group. However, neither Kv1.5 protein nor KCNA5 mRNA had significant differences in adult and aged groups, non-RHD and RHD group, and men and women group of AF. CONCLUSIONS: The expression of Kv1.5 channel protein changes with AF but not with age, RHD, and sex in AF.
No takes yet. Share an insight, caveat, or question.
Xiaorong Zeng (2015) conducted a cross-sectional in Atrial Fibrillation (n=46). Atrial fibrillation vs. Normal sinus rhythm was evaluated on Kv1.5 protein expression. Atrial fibrillation was associated with a significant decrease in right atrial Kv1.5 protein expression compared to normal sinus rhythm, regardless of age, sex, or rheumatic heart disease.
Synapse has enriched 10 related papers. Consider them for comparative context: