Key result
Patients with chronic atrial fibrillation and mitral valvular heart disease exhibited significantly reduced atrial mRNA expression of L-type Ca2+ channels, RyR2, SERCA2, Kv1.5, and KChIP2 compared to those with sinus rhythm.
Observational (n=17)
No
Chronic atrial fibrillation in patients with mitral valvular heart disease is associated with significant molecular remodeling of atrial ion channels, which may contribute to the maintenance of the arrhythmia.
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Altered atrial ion channel expression in this small Korean cohort supports electrical remodeling in valvular AF; leaves open clinical relevance pending larger studies.
Oh et al. (2010) conducted an observational in Chronic Atrial Fibrillation and Mitral Valvular Heart Disease (n=17). Chronic atrial fibrillation and mitral valvular heart disease vs. Sinus rhythm was evaluated on Atrial mRNA expression of ion channels and related molecules. Patients with chronic atrial fibrillation and mitral valvular heart disease exhibited significantly reduced atrial mRNA expression of L-type Ca2+ channels, RyR2, SERCA2, Kv1.5, and KChIP2 compared to those with sinus rhythm.
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