Key result
Isoproterenol does not directly activate the transient outward current in rabbit ventricular myocytes, but instead activates a time-independent chloride current.
Why the study?
Does isoproterenol activate the transient outward current or a chloride current in rabbit ventricular myocytes?
Population
Rabbit ventricular myocytes
Comparison
Isoproterenol (ISO; 1 microM) vs Baseline conditions, different holding…
Design
Preclinical
Authors
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Refines beta-adrenergic current modulation in rabbit myocytes; leaves open translation to human electrophysiology.
Does isoproterenol activate the transient outward current or a chloride current in rabbit ventricular myocytes?
Beta-adrenergic stimulation with isoproterenol activates a time-independent chloride current rather than the transient outward current in rabbit ventricular myocytes.
Harvey et al. (1989) studied this question. Isoproterenol was evaluated on Activation of transient outward current (Ito) vs chloride current (ICl). Isoproterenol does not directly activate the transient outward current in rabbit ventricular myocytes, but instead activates a time-independent chloride current.
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