Contribution of Na⁺-Ca²⁺Exchange to Stimulation of Transient Inward Current by Isoproterenol in Rabbit Cardiac Purkinje Fibers

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Structured PICO

Population

Rabbit cardiac Purkinje fibers

Intervention

Isoproterenol (0.01 to 5.0 mumol/L) or forskolin (1 mumol/L) in the presence or absence of extracellular sodium ([Na+]o)

Comparator

Baseline conditions or absence of extracellular sodium (substituted with N-methyl-D-glucamine chloride)

Outcome

Transient inward current (TI) and its reversal potential (EREV)surrogate

Beta-adrenergic stimulation of the arrhythmogenic transient inward current in rabbit cardiac Purkinje fibers is mediated by Na(+)-Ca2+ exchange.

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Supports NCX mediation of beta-adrenergic TI in rabbit Purkinje fibers; leaves open translation to human arrhythmogenesis.

Han et al. (1995) studied this question.

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