Key result
Increased central aortic pulse pressure in men is independently associated with more severe coronary atherosclerosis, demonstrated by a higher number of diseased coronary vessels in the highest versus lowest pulse pressure tertile (1.99 vs 1.51, p<0.01).
Why the study?
Does higher invasively measured central aortic pulse pressure correlate with increased severity of coronary atherosclerosis in stable male patients?
Cross-Sectional (n=1,075)
No
Does higher invasively measured central aortic pulse pressure correlate with increased severity of coronary atherosclerosis in stable male patients?
Absolute Event Rate: 1.99% vs 1.51%
p-value: p=<0.01
Invasively measured central aortic pulse pressure is independently associated with the angiographic severity of coronary atherosclerosis in stable male patients.
Central aortic pulse pressure may aid risk stratification in stable men; hypothesis-generating and requires prospective validation before clinical adoption.
A high pulse pressure (PP) is a marker of increased artery stiffness and represents a well-established independent predictor for cardiovascular morbidity and mortality. The objective of the research was to determine whether invasively measured central aortic PP was related to the presence and severity of coronary artery disease. In total 1075 consecutive stable male patients undergoing diagnostic coronary angiography with a preserved left ventricular function were included. Diseased coronary vessel (DCV) was defined by the presence of >50 % stenosis. Men were divided into 3 groups according to the increased value of PP. The average PP in the tertiles was 47.8+/-7.1 vs. 67.0+/-4.9 vs. 91.3+/-12.8 mm Hg (p<0.01). The significant differences of DCV was found among tertiles (1.51+/-1.11 vs 1.80+/-1.04 vs. 1.99+/-0.98 DCV, p<0.01). Aortic PP together with age and hyperlipoproteinemia were found as factors with an independent relationship to DCV according to multivariate linear regression. In conclusions the increased value of aortic PP in the male population is independently connected with more severe atherosclerosis evaluated by the significant number of DCV.
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Pařenica et al. (2011) conducted a cross-sectional in Coronary artery disease (n=1,075). High aortic pulse pressure vs. Low aortic pulse pressure was evaluated on Number of diseased coronary vessels (>50% stenosis) (p=<0.01). Increased central aortic pulse pressure in men is independently associated with more severe coronary atherosclerosis, demonstrated by a higher number of diseased coronary vessels in the highest versus lowest pulse pressure tertile (1.99 vs 1.51, p<0.01).
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