Key result
Right ventricular hypertrophy secondary to pulmonary hypertension was associated with severely decreased septal displacement (P<0.005) and 2-D strains (P<0.05) compared to normal volunteers.
Why the study?
Does MRI with magnetization tagging identify differences in right ventricular wall mechanics between patients with pulmonary hypertension and normal volunteers?
Cross-Sectional (n=17)
Does MRI with magnetization tagging identify differences in right ventricular wall mechanics between patients with pulmonary hypertension and normal volunteers?
p-value: p=<0.005
MRI with magnetization tagging can detect regional abnormalities in right ventricular wall mechanics, specifically reduced septal displacement and strain, in patients with pulmonary hypertension compared to normal volunteers.
MRI tagging may detect RV septal changes in PH; hypothesis-generating and should not yet alter practice.
Right ventricular hypertrophy (RVH) and RV dysfunction are difficult to evaluate due to the complex shape of the RV and prognostic limitations of conventional global function parameters. We used MRI with magnetization tagging to measure 2-D systolic motion and deformation of the right ventricular free wall (RVFW) and septum (SEPT) in 5 patients with RVH secondary to pulmonary hypertension, and 12 normal volunteers (NL). Regional displacement (D) and 2-D principal strains in the short-axis plane were averaged at basal, midventricular and apical levels. SEPT D was severely decreased at all levels in RVH vs. NL (P<0.005). In RVH, RVFW D was higher than SEPT D (P<0.02). The 2-D strains were reduced in SEPT at all levels in RVH vs. NL (P<0.05). This technique may permit the study of progression and regression of RVH in various disease states.
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Fayad et al. (2002) conducted a cross-sectional in Right ventricular hypertrophy secondary to pulmonary hypertension (n=17). Right ventricular hypertrophy secondary to pulmonary hypertension vs. Normal volunteers was evaluated on Regional displacement and 2-D principal strains of the right ventricular free wall and septum (p=<0.005). Right ventricular hypertrophy secondary to pulmonary hypertension was associated with severely decreased septal displacement (P<0.005) and 2-D strains (P<0.05) compared to normal volunteers.
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