Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women
Why the study?
Is sympathetic activity, as measured by plasma norepinephrine, associated with age-related reductions in vascular endothelial function in healthy adults?
Population
314 healthy men (n=187) and women (n=127) varying in age
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports sympathetic contribution to endothelial dysfunction in aging women; hypothesis-generating and does not yet inform clinical practice.
Structured PICO
Is sympathetic activity, as measured by plasma norepinephrine, associated with age-related reductions in vascular endothelial function in healthy adults?
P
Population
314 healthy men (n=187) and women (n=127) varying in age
O
Outcome
Vascular endothelial function (endothelium-dependent dilation) measured by brachial artery flow-mediated dilation (FMD)surrogate
Increased sympathetic activity, indicated by plasma norepinephrine, is independently associated with reduced vascular endothelial function with aging, particularly in healthy women.
Cite This Study
Kaplon et al. (2011) studied this question.