What question did this study set out to answer?

September 1, 1999Journal of Internal MedicineOpen Access

Effects of age, gender and metabolic factors on endothelium‐dependent vasodilation: a population‐based study

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Population

66 healthy subjects (36 men, 30 women), aged 20-69 years, from a population-based study.

Design

Cross-sectional

Authors

MSMahziar SarabiUppsala University Hospital JMJonas MillgårdSunderby sjukhus LLLars LindUppsala University

Discussion

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Implication

Sex-specific predictors of endothelial function may differ by gender; hypothesis-generating and requires prospective validation before informing practice or trials.

Key Points

To evaluate the interplay between age, gender, and metabolic factors on endothelium-dependent vasodilation in healthy individuals.
Assessed 36 healthy men and 30 healthy women aged 20–69 years in a tertiary university hospital setting.
Measured forearm blood flow using venous occlusion plethysmography at rest, during reactive hyperaemia, and during local infusions of metacholine (for endothelium-dependent vasodilation) and sodium nitroprusside (for endothelium-independent vasodilation).
Age was inversely related to endothelium-dependent vasodilation in both men (r = -0.41, P < 0.05) and women (r = -0.61, P < 0.01), with premenopausal women showing greater vasodilation than age-matched men (635 ± 186% vs. 502 ± 269%, P < 0.05) before declining to similar levels post-menopause (374 ± 141% vs. 370 ± 185%).
Multiple regression analysis revealed that fasting blood glucose and waist-to-hip ratio were the only significant independent predictors of endothelium-dependent vasodilation in men (P < 0.01 for both), whereas age was the sole significant independent predictor in women (P < 0.01).

Structured PICO

Population

66 healthy subjects (36 men, 30 women), aged 20-69 years, from a population-based study.

Intervention

Measurement of forearm blood flow at rest and during local infusions of metacholine (2 and 4 microg min-1) and sodium nitroprusside (5 and 10 microg min-1) and during reactive hyperaemia.

Outcome

Endothelium-dependent vasodilation (EDV) evaluated by forearm blood flow during metacholine infusion.surrogate

The determinants of endothelial function differ by sex, with metabolic factors playing a larger role in men and age being the primary driver in women.

Cite This Study

Sarabi et al. (1999) studied this question.

synapsesocial.com/papers/6a72c2f0b27f158178281f50 https://doi.org/10.1046/j.1365-2796.1999.00542.x

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Implication

Sex-specific predictors of endothelial function may differ by gender; hypothesis-generating and requires prospective validation before informing practice or trials.

Effects of age, gender and metabolic factors on endothelium‐dependent vasodilation: a population‐based study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of age, gender and metabolic factors on endothelium‐dependent vasodilation: a population‐based study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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