Key result
The mast cell chymase gene A3255 allele was associated with a /dl higher serum HDL cholesterol level compared to the GG genotype, but showed no association with blood pressure.
Why the study?
Does the MCC G3255A polymorphism affect blood pressure and lipid levels in a general Japanese population?
Cross-Sectional (n=1,046)
No
Does the MCC G3255A polymorphism affect blood pressure and lipid levels in a general Japanese population?
Answers are grounded in this paper and cite their sources.
The MCC G3255A polymorphism is not associated with blood pressure but is independently associated with higher HDL cholesterol levels, suggesting a potential role in lipid metabolism.
Two enzymes, chymase and angiotensin converting enzyme (ACE), are involved in the production of angiotensin II. Our previous study revealed the male-specific effect of the ACE DD genotype on the risk for hypertension, but the genetic role of chymase remains unclear. In the present study, we report the results of an association study involving 1,046 subjects recruited from a general population in Ohasama, a rural community in the northern part of Japan. In addition to casual blood pressure (casual BP) measurement, home BP measurements were obtained from all participants. There were no differences in either home or casual BP values according to G3255A polymorphism of the mast cell chymase gene (MCC). HDL cholesterol level was significantly higher among carriers of the A3255 allele (p<0.04). After adjustment for confounding factors, the A3255 allele was still shown to have an effect on HDL cholesterol metabolism (p<0.03). Multiple regression analysis showed that MCC polymorphism was significantly and independently related to serum HDL cholesterol level. In conclusion, G3255A polymorphism of MCC is not directly associated with blood pressure but may modulate the prevalence of hypertensive complications via alteration of lipid metabolism.
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Fukuda et al. (2002) conducted a cross-sectional in General population (cardiovascular risk) (n=1,046). Mast cell chymase gene (MCC) G3255A polymorphism (A3255 allele) vs. GG genotype was evaluated on Serum HDL-cholesterol level (MD 1.82 mg/dl, p=0.018). The mast cell chymase gene A3255 allele was associated with a /dl higher serum HDL cholesterol level compared to the GG genotype, but showed no association with blood pressure.
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