Key result
Estradiol and estradiol+progesterone restored altered vascular reactivity to norepinephrine and acetylcholine and normalized PGF(2alpha) release in ovariectomized spontaneously hypertensive rats.
Why the study?
Do estrogen and progesterone attenuate the generation of endothelium-derived contracting factors in microvessels of spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR), including estrous (OE) and ovariectomized (OVX) models
Comparison
Estradiol for 24 hours or 15 days, or… vs Untreated ovariectomized SHR and estrous SHR
Design
Preclinical
Follow-up
up to 15 days
Authors
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Hypothesis-generating for hormonal modulation of vascular reactivity in hypertension; leaves open human translation.
Do estrogen and progesterone attenuate the generation of endothelium-derived contracting factors in microvessels of spontaneously hypertensive rats?
Estrogen may protect female spontaneously hypertensive rats against severe hypertension partly by decreasing the synthesis of endothelium-derived contracting factors such as PGH(2)/PGF(2alpha) and superoxide anion.
Dantas et al. (1999) studied Hypertension. Estradiol and estradiol+progesterone vs. Ovariectomized SHR without treatment was evaluated on Vascular reactivity to norepinephrine and acetylcholine, and release of PGF(2alpha). Estradiol and estradiol+progesterone restored altered vascular reactivity to norepinephrine and acetylcholine and normalized PGF(2alpha) release in ovariectomized spontaneously hypertensive rats.
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