Population
Isolated aortas from Sprague-Dawley rats
Comparison
Exposure to vasoconstrictor prostanoids and… vs Control conditions or co-administration with…
Design
Preclinical
Authors
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May preserve endothelial function via PGH2 receptor or superoxide modulation in animals; leaves open relevance to human disease.
Activation of PGH2 receptors causes selective impairment of endothelium-dependent relaxations through the generation of oxygen-derived free radicals in the endothelium.
Belay Tesfamariam (1994) studied this question.
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