Why the study?
Does treatment with COX-2 inhibitors or ROS scavengers improve endothelial function and reduce blood pressure in renovascular hypertensive rats?
Population
Renovascular hypertensive rats
Comparison
Acute treatment with reactive oxygen species… vs Untreated renovascular hypertensive rats (implied)
Design
Preclinical
Follow-up
5 weeks
Authors
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Should not change clinical practice; hypothesis-generating for COX-2 or ROS pathways as targets in renovascular hypertension.
Does treatment with COX-2 inhibitors or ROS scavengers improve endothelial function and reduce blood pressure in renovascular hypertensive rats?
Oxidative stress initiates increased COX-2 activity, and COX-2-derived PGF2α mediates endothelial dysfunction in renovascular hypertension, suggesting a potential therapeutic target.
Tian et al. (2011) studied this question.
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