Key result
Higher estimated pulse wave velocity is linked to ~3-point lower learning scores in HIV.
Why the study?
Although HIV is associated with rapid vascular aging, it is unknown whether arterial stiffness mediates changes in cognitive function.
Are estimated markers of arterial stiffness associated with neurocognitive impairment in adults with HIV?
Population
165 people with HIV
Comparison
Estimated markers of arterial stiffness
Design
Secondary analysis of an observational study
Authors
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Hypothesis-generating for vascular aging in HIV cognition; leaves open causality and precludes practice change.
Observational (n=165)
Are estimated markers of arterial stiffness associated with neurocognitive impairment in adults with HIV?
Mean Difference: -2.95 (95% CI -5.13–-0.77)
Estimated markers of arterial stiffness are weakly associated with lower neurocognitive functioning in people with HIV, suggesting a role for vascular aging in cognitive decline.
Jones et al. (2023) conducted an observational in HIV (n=165). Estimated markers of arterial stiffness was evaluated on T scores in learning (MD -2.95, 95% CI -5.13 to -0.77). Increases in estimated pulse wave velocity were associated with lower T scores in learning (MD -2.95; 95% CI -5.13 to -0.77) among people with HIV.
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