Key result
A diastolic blood pressure <60 mm Hg was associated with increased carotid intima-media thickness compared to 60-69 mm Hg (difference 0.033 mm; 95% CI 0.001-0.065), indicating a J-shaped relationship.
Why the study?
Is low diastolic blood pressure associated with increased carotid intima-media thickness in elderly subjects?
Population
930 subjects not currently using blood pressure-lowering drugs, drawn from the population-based Rotterdam…
Comparison
Diastolic blood pressure <60 mm Hg vs Diastolic blood pressure 60-69 mm Hg
Design
Cross-sectional
Authors
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Caution advised against targeting diastolic BP <60 mm Hg in older adults; observational data leave open causality for carotid atherosclerosis.
Cross-Sectional (n=930)
No
Is low diastolic blood pressure associated with increased carotid intima-media thickness in elderly subjects?
Mean Difference: 0.033 (95% CI 0.001–0.065)
A J-shaped association exists between diastolic blood pressure and carotid atherosclerosis in the elderly, suggesting that low diastolic pressure may reflect widespread arterial stiffening and atherosclerosis.
Michiel L. Bots (1996) conducted a cross-sectional in Atherosclerosis (n=930). Low diastolic blood pressure (<60 mm Hg) vs. Diastolic blood pressure 60-69 mm Hg was evaluated on Intima-media thickness of the common carotid artery (MD 0.033, 95% CI 0.001-0.065). A diastolic blood pressure <60 mm Hg was associated with increased carotid intima-media thickness compared to 60-69 mm Hg (difference 0.033 mm; 95% CI 0.001-0.065), indicating a J-shaped relationship.
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