Key result
Heart rate history modulates beat-to-beat changes in fatigue, transforming transient nodal responses and hysteresis observed during stimulation ramps in isolated rabbit hearts.
Why the study?
Does heart rate history affect transient AV nodal responses in isolated rabbit hearts?
Population
Isolated rabbit heart preparations
Comparison
Ramp stimulation sequences applied to the atrium… vs Different initial conditions
Design
Preclinical
Authors
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Heart rate history should inform AV nodal models; leaves open translation to human conduction.
Does heart rate history affect transient AV nodal responses in isolated rabbit hearts?
Heart rate history modulates transient AV nodal responses and hysteresis through beat-to-beat changes in fatigue, highlighting the need to account for previous nodal history in interpreting these responses.
Zhao et al. (1996) studied this question. Ramp stimulation sequences from different initial conditions vs. Control basic cycle length was evaluated on Nodal conduction times (NCT) and hysteresis loops. Heart rate history modulates beat-to-beat changes in fatigue, transforming transient nodal responses and hysteresis observed during stimulation ramps in isolated rabbit hearts.
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