Key result
The coupling of breathing and cardiovascular regulation acts as a main source of short-term variability and a potent confounding factor in acute clinical environments like the ICU and OR.
This review highlights the importance of properly describing cardiorespiratory coupling in cardiovascular regulation models, especially in acute clinical settings where sedation and forced ventilation alter reflex responses.
Highlights need to account for cardiorespiratory coupling in ICU/OR monitoring; hypothesis-generating for refined variability models.
The coupling of breathing and cardiovascular (CV) regulation is a main source of spontaneous short term CV variability signals. However, intense interaction with short term regulations involving baroreflex, vasomotion, and central drives and the ubiquitous presence of respiratory driven/modulated responses may render it a potent confounding factor, when not properly described. Major challenges are found in the acute clinical environment, e.g. ICU and OR, where monitoring cardiorespiratory coupling and CV regulation is of high impact, while sedation and forced ventilation extensively change the reflex portrait. A review is here attempted, finalized to approach ICU recordings in the ShockOmics EC project, aimed at integrating biomolecular and CV data in acute shock, under diffuse receptor cleavage and autonomic impairment.
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Baselli et al. (2014) conducted a review in Cardiovascular regulation in acute clinical environments. Respiration in cardiovascular regulation models was evaluated. The coupling of breathing and cardiovascular regulation acts as a main source of short-term variability and a potent confounding factor in acute clinical environments like the ICU and OR.
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