Key result
MR-guided percutaneous intramyocardial injection of gadodiamide was feasible in all 7 pigs, with T1 values significantly differing by contrast concentration and decreasing over 30 minutes.
p-value: p=<.001
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Supports preclinical optimization of MR-guided intramyocardial delivery; leaves open human safety and efficacy trials.
Krombach et al. (2005) studied this question. MR-guided percutaneous intramyocardial injection of gadodiamide vs. Different concentration / remote myocardium was evaluated on Local changes in T1 values and size of the contrast material-enhanced region (p=<.001). MR-guided percutaneous intramyocardial injection of gadodiamide was feasible in all 7 pigs, with T1 values significantly differing by contrast concentration and decreasing over 30 minutes.
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