Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 2000European Journal of PharmacologyOpen Access

Ethanol alters angiotensin II stimulated mitogen activated protein kinase in hepatocytes: agonist selectivity and ethanol metabolic independence

View Full Paper
Ask AI
Bookmark
Share

Key result

Ethanol exposure (100 mM) potentiated angiotensin II and epinephrine-stimulated MAPK activity in rat hepatocytes, an effect that was agonist-selective and independent of ethanol metabolism.

Population

Hepatocytes isolated from rat liver

Comparison

Ethanol exposure for 24 h followed by agonist… vs Hepatocytes treated without ethanol

Design

Preclinical

Follow-up

24 hours

Authors

YWYu‐I WengUniversity of North Carolina at Chapel HillSSShivendra D. ShuklaChhatrapati Shahu Ji Maharaj University

Discussion

Loading...

Member takes

Implication

Does not support changes in clinical ethanol guidance; leaves open translation of rat hepatocyte MAPK effects to human disease.

Structured PICO

P
Population
Hepatocytes isolated from rat liver
I
Intervention
Ethanol exposure (100 mM) for 24 h followed by agonist stimulation (angiotensin II, epinephrine, etc.)
C
Comparator
Hepatocytes treated without ethanol
O
Outcome
Mitogen-activated protein kinase (MAPK) activity (p42 and p44)surrogate

Ethanol potentiates angiotensin II-stimulated MAPK activity in rat hepatocytes through a G-protein-dependent mechanism that is independent of ethanol metabolism.

Cite This Study

Weng et al. (2000) studied this question. Ethanol vs. Without ethanol was evaluated on MAPK activity. Ethanol exposure (100 mM) potentiated angiotensin II and epinephrine-stimulated MAPK activity in rat hepatocytes, an effect that was agonist-selective and independent of ethanol metabolism.

synapsesocial.com/papers/6a23a8b4edf75d41fd08b13chttps://doi.org/10.1016/s0014-2999(00)00313-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II Type 2 Receptor Inhibits Cell Proliferation and Activates Tyrosine Phosphatase1996 · 102 citations
  2. 2Angiotensin II Signal Transduction in Vascular Smooth Muscle1997 · 307 citations
  3. 3Protein kinase C and adaptation to ethanol1994 · 22 citations
  4. 4Biochemical and Molecular Basis of Alcohol-Induced Injury to Liver and Other Tissues1988 · 449 citations
  5. 5Comparison of the effects of [leucine]enkephalin and angiotensin on hepatic carbohydrate and cyclic nucleotide metabolism1988 · 9 citations