Key result
Ethanol inhibited rGRH-stimulated growth hormone release by up to 54% (P<0.01) in rat pituitary cells in vitro, primarily via the adenylate cyclase-cAMP pathway.
Population
Primary culture of rat anterior pituitary cells and a pituitary somatomammotroph cell line
Comparison
Ethanol (30, 100, and 300 mM) vs Basal conditions (no ethanol)
Design
Preclinical
Follow-up
up to 4 hours
Authors
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Ethanol may inhibit pituitary GH release in vitro; leaves open in vivo translation and clinical relevance in alcohol users.
p-value: p=<0.01
Ethanol exerts multiple effects on systems mediating GH release from the pituitary in vitro, primarily inhibiting GH secretion via the adenylate cyclase-cAMP pathway.
Soszyński et al. (1992) studied In vitro rat pituitary cells. Ethanol was evaluated on rGRH-stimulated rGH release (p=<0.01). Ethanol inhibited rGRH-stimulated growth hormone release by up to 54% (P<0.01) in rat pituitary cells in vitro, primarily via the adenylate cyclase-cAMP pathway.
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