December 1, 1992Endocrinology

Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat.

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Why the study?

Does ethanol administration inhibit the GH-releasing hormone-GH-IGF-I axis in rats?

Population

Chronically cannulated unanesthetized rats (n=18)

Comparison

Ethanol (5%)-liquid diet for 6 days vs Isocalorically pair-fed controls and ad…

Design

Preclinical

Follow-up

6 days

Authors

PSPiotr SoszyńskiBrigham and Women's Hospital LFL A FrohmanUniversity of Illinois Chicago

Discussion

Member takes

Implication

Ethanol suppresses GH in rats; leaves open whether hypothalamic GHRH effects translate to humans.

Structured PICO

Does ethanol administration inhibit the GH-releasing hormone-GH-IGF-I axis in rats?

Population

Chronically cannulated unanesthetized rats (n=18)

Intervention

Ethanol (5%)-liquid diet for 6 days

Comparator

Isocalorically pair-fed controls and ad libitum-fed animals

Outcome

Spontaneous secretory pattern of GH, plasma IGF-I concentrations, hypothalamic GHRH and somatostatin, and pituitary GH mRNA levelssurrogate

Ethanol inhibits growth hormone secretion primarily at the hypothalamic level by impairing GHRH gene expression in a rat model.

Cite This Study

Soszyński et al. (1992) studied this question.

synapsesocial.com/papers/6a929d7fcfe2d75514a60376 https://doi.org/10.1210/endo.131.6.1359962

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Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibitory effects of ethanol on the growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-I axis in the rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider