Key result
Moderate ethanol administration facilitated recovery from insulin-induced hypoglycemia despite significantly reducing hypoglycemia-induced serum GH, cortisol, and glucagon responses (P<0.05-0.005).
Why the study?
Does moderate ethanol administration affect the counterregulatory response and recovery from insulin-induced hypoglycemia in normal men?
Population
8 normal men, aged 26 +/- 6 yr, after an overnight fast
Comparison
Moderate ethanol administration prior to… vs Control study prior to insulin-induced…
Design
Other
Follow-up
acute
Authors
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May aid hypoglycemia recovery via insulin resistance in healthy men; leaves open relevance to diabetes counterregulation.
Does moderate ethanol administration affect the counterregulatory response and recovery from insulin-induced hypoglycemia in normal men?
Absolute Event Rate: 2.5% vs 2.3%
Moderate ethanol administration facilitates recovery from insulin-induced hypoglycemia despite reducing counterregulatory hormone responses, suggesting a role for ethanol-induced insulin resistance.
Kolaczynski et al. (1988) studied Healthy volunteers (normal men) (n=8). Moderate ethanol administration (oral and iv) vs. Control (absence of ethanol) was evaluated on Plasma glucose nadir after insulin administration (mmol/L). Moderate ethanol administration facilitated recovery from insulin-induced hypoglycemia despite significantly reducing hypoglycemia-induced serum GH, cortisol, and glucagon responses (P<0.05-0.005).
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