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November 15, 1985Biochemical JournalOpen Access

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

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To investigate the formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor activation in rat cortical slices.
Used carbachol to stimulate muscarinic receptors in rat cortical slices prelabelled with myo-[2-3H]inositol.
Conducted chromatographic behavior analysis and partial dephosphorylation experiments to characterize the formed compounds.
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following stimulation (specific product identified).
Inositol 1,3,4,5-tetrakisphosphate can be converted to inositol 1,3,4-trisphosphate by specific enzyme action.
Indicates potential role of inositol 1,3,4,5-tetrakisphosphate as a second messenger.

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Randomized trial examines the rapid formation of inositol polyphosphate in rat cortical slices, suggesting its role as a second messenger.

Batty et al. (1985) studied this question.

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Randomized trial examines the rapid formation of inositol polyphosphate in rat cortical slices, suggesting its role as a second messenger.