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October 9, 2011Journal of Interventional Cardiology

Long‐Term Safety and Effectiveness of Drug‐Eluting Stents Compared to Bare Metal Stents following Successful PCI in Non‐ST‐Elevation Myocardial Infarction: Findings from the Guthrie Health Off‐Label StenT (GHOST) Registry

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Why the study?

Does drug-eluting stent implantation reduce death, recurrent MI, or stent thrombosis compared to bare metal stents in patients with NSTEMI undergoing PCI?

Population

674 patients with non-ST-segment elevation myocardial infarction who underwent successful percutaneous…

Comparison

Drug-eluting stents (DES) (n=323) vs Bare metal stents (BMS) (n=351)

Design

Cohort

Follow-up

mean 1333 ± 659 days

Authors

KHKishore J. HarjaiInterventional / Structural CardiologySSSudhakar SatturSUNY Upstate Medical UniversityPOPamela OrshawGuthrie Foundation

Discussion

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Overview

DES associated with similar long-term safety but lower TVR in NSTEMI PCI; leaves open whether randomized trials would confirm.

Structured PICO

Does drug-eluting stent implantation reduce death, recurrent MI, or stent thrombosis compared to bare metal stents in patients with NSTEMI undergoing PCI?

P
Population
674 patients with non-ST-segment elevation myocardial infarction (NSTEMI) who underwent successful percutaneous coronary intervention (PCI)
I
Intervention
Drug-eluting stents (DES) (n=323)
C
Comparator
Bare metal stents (BMS) (n=351)
O
Outcome
Time to occurrence of death or nonfatal recurrent myocardial infarction (MI), and stent thrombosis (ST)composite

In NSTEMI patients undergoing PCI, drug-eluting stents are as safe as bare metal stents at long-term follow-up (>3 years) and significantly reduce the need for target vessel revascularization.

Cite This Study

Harjai et al. (2011) studied this question.

synapsesocial.com/papers/6a23a919fdd7df511fd31af5https://doi.org/10.1111/j.1540-8183.2011.00677.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevations in Troponin T and I Are Associated With Abnormal Tissue Level Perfusion2002 · 124 citations
  2. 2Safety and Efficacy of Drug-Eluting Stents Compared With Bare Metal Stents in ST-Elevation Myocardial Infarction2010 · 2 citations
  3. 3Drug-Eluting or Bare-Metal Stents for Acute Myocardial Infarction2008 · 245 citations
  4. 4Safety and efficacy of drug-eluting vs. bare metal stents in patients with diabetes mellitus: long-term follow-up in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)2009 · 67 citations
  5. 5Long-Term Safety and Efficacy of Drug-Eluting versus Bare-Metal Stents in Sweden2009 · 237 citations