What question did this study set out to answer?

To investigate how cross-innervation affects the biochemical properties and behavior of myosin in rat muscles.

March 1, 1971The Journal of PhysiologyOpen Access

The transformation of myosin in cross‐innervated rat muscles

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Population

Rat extensor digitorum longus (EDL) and soleus (SOL) muscles

Comparison

Cross-innervation (X-EDL, X-SOL) vs Normal and self-innervated muscles

Design

Preclinical

Authors

MBMichael BárányUniversity of Edinburgh RCR. CloseAustralian National University

Discussion

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Implication

Neural control may shape myosin properties in rodent muscle; leaves open human translation and clinical relevance.

Key Points

To investigate how cross-innervation affects the biochemical properties and behavior of myosin in rat muscles.
Determined muscle contraction characteristics at 35 degrees C for various muscle types (normal, self-innervated, cross-innervated).
Conducted biochemical analyses of myosin and actomyosin, focusing on ATPase activities and structural changes.
Analyzed the influences of pH and ATP-induced reactions on myosin structure.
ATPase activities of cross-innervated muscles (X-EDL, X-SOL) decreased to levels similar to self-innervated and normal muscles.
Myosin structure of X-EDL transformed closer to that of normal soleus (N-SOL) or self-innervated soleus (S-SOL), while X-SOL structure aligned with normal extensor digitorum longus (N-EDL).
No differences in myosin yield across different muscle types.

Structured PICO

Population

Rat extensor digitorum longus (EDL) and soleus (SOL) muscles

Intervention

Cross-innervation (X-EDL, X-SOL)

Comparator

Normal (N-EDL, N-SOL) and self-innervated (S-EDL, S-SOL) muscles

Outcome

Characteristics of isometric twitch and tetanic contractions, and biochemical properties of myosin and actomyosin (ATPase activities, superprecipitation rates, structural changes)surrogate

Cross-innervation of fast and slow rat skeletal muscles induces a reciprocal transformation in the biochemical and structural properties of their myosin.

Cite This Study

Bárány et al. (1971) studied this question.

synapsesocial.com/papers/6a23abf8bcda00f3e0a01eb7 https://doi.org/10.1113/jphysiol.1971.sp009393

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The transformation of myosin in cross‐innervated rat muscles

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The transformation of myosin in cross‐innervated rat muscles

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider