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In the short period of time since their introduction into clinical practice, almost 1,000 scientific papers have been written concerning beta‐receptor‐blocking drugs. This review does not cover the whole of this literature as it is particularly concerned with the effects of beta‐blocking drugs in man. To simplify presentation the review is divided into six main sections. The first deals with the nature of beta blockade and the second with structure activity relationships among beta‐blocking drugs. The third section is an account of the pharmacology of beta‐blocking drugs, mainly from the standpoint of their action on vascular, bronchial, and cardiac muscle and is chiefly derived from animal data. The fourth section deals with the clinical pharmacology, particularly circulatory and metabolic aspects, but it also includes some relevant animal data, especially that concerned with metabolic effects. The fifth and largest section deals with the clinical use of beta‐blocking drugs. The final section summarizes the adverse reactions so far reported with these drugs.
Dollery et al. (Sat,) studied this question.