What question did this study set out to answer?

This study aims to evaluate the relationship between antidepressant use and ischemic stroke risk in elderly outpatients.

May 5, 2010Journal of Clinical Psychopharmacology

Risk of Ischemic Stroke Associated With Antidepressant Drug Use in Elderly Persons

View Full Paper

Ask AI

Bookmark

Why the study?

Does the use of different types of antidepressants increase the risk of ischemic stroke in elderly outpatients?

Key Points

This study aims to evaluate the relationship between antidepressant use and ischemic stroke risk in elderly outpatients.
Conducted a population-based, nested, case-control study in individuals aged 65 and older from 1996 to 2005.
Matched cases with validated first ischemic stroke to controls based on year of birth, sex, and index date.
Used conditional logistic regression to compare stroke risk among antidepressant users and nonusers.
Identified 996 incident ischemic strokes.
Current SSRI use had an odds ratio of 1.55 (95% CI, 1.07-2.25) compared to nonuse, particularly for short-term use (less than six months).
No significant associations were found for current use of tricyclic or other antidepressants.

Structured PICO

Does the use of different types of antidepressants increase the risk of ischemic stroke in elderly outpatients?

Population

Elderly outpatients 65 years and older in the Integrated Primary Care Information database (1996-2005). Cases were patients with a validated first ischemic stroke (n=996), and controls were matched on year of birth, sex, and index date.

Intervention

Antidepressant drug use (selective serotonin reuptake inhibitors [SSRIs], tricyclic, and other antidepressants), categorized by current or past use, dose, and duration.

Comparator

Nonuse of antidepressants.

Outcome

First ischemic stroke.hard clinical

In elderly patients, current use of SSRIs, particularly for less than six months, is associated with an increased risk of ischemic stroke compared to nonuse.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support closer monitoring of new SSRI starts in elderly patients; leaves open whether the association is causal.

Cite This Study

Trifirò et al. (2010) studied this question.

synapsesocial.com/papers/6a23b3f49c28b44ec7d342b4 https://doi.org/10.1097/jcp.0b013e3181dca10a

View Full Paper

Ask AI

Bookmark

Risk of Ischemic Stroke Associated With Antidepressant Drug Use in Elderly Persons

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Risk of Ischemic Stroke Associated With Antidepressant Drug Use in Elderly Persons

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider