Key result
Antidepressant exposure was associated with an increased risk of stroke (adjusted OR 1.48; 95% CI 1.37-1.59) using 14-day time windows.
Why the study?
Does antidepressant use increase the risk of stroke?
Case-Control (n=24,214)
Does antidepressant use increase the risk of stroke?
Odds Ratio: 1.48 (95% CI 1.37–1.59)
Antidepressant use, particularly agents with high serotonin transporter inhibition, is associated with an increased risk of stroke.
No takes yet. Share an insight, caveat, or question.
Should not yet change prescribing; leaves open causality and confounding in this Level 4 evidence.
Wu et al. (2011) conducted a case-control in Stroke (n=24,214). Antidepressant medications vs. Control time windows was evaluated on Stroke risk (OR 1.48, 95% CI 1.37-1.59). Antidepressant exposure was associated with an increased risk of stroke (adjusted OR 1.48; 95% CI 1.37-1.59) using 14-day time windows.
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