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October 30, 2017Physiological ReportsOpen Access

Linking metabolic and contractile dysfunction in aged cardiac myocytes

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Key result

Old myocytes demonstrated decrements in mitochondrial NADH during continuous stimulation and exhibited impaired contractile function to workload and metabolic stress compared to young myocytes.

Population

Isolated left ventricular myocytes from young (Y) and old (O) FBN rats

Comparison

Continuous contraction at 2 Hz or 4 Hz for 10… vs Young vs. old myocytes under resting and stress…

Design

Preclinical

Follow-up

10 minutes

Authors

GBGregory P. BartonVascular / Pulmonary VascularWLWillem J. de LangeUniversity of Wisconsin–MadisonJRJ. Carter RalpheUniversity of Wisconsin–Madison

Discussion

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Implication

Suggests caution with stress in aged hearts; leaves open NADH-targeted interventions in human aging.

Structured PICO

P
Population
Isolated left ventricular myocytes from young and old FBN rats.
E
Exposure
Continuous contraction at 2 Hz or 4 Hz for 10 min, metabolic disruption with rotenone, and increased workload with isoproterenol (ISO)
C
Comparator
Young vs. old myocytes under resting and stress conditions
O
Outcome
Mitochondrial NADH ([NADH]m) and properties of shortening (peak shortening and rate of shortening) at onset (T0) and after 10 min (T10) of continuous contractionsurrogate

Age-related susceptibility to stress-induced contractile dysfunction in cardiac myocytes may be linked to altered cellular energetics and metabolic disruption.

Cite This Study

Barton et al. (2017) studied Aging-related cardiac contractile dysfunction. Aging (old vs young myocytes) vs. Young myocytes was evaluated on Mitochondrial NADH ([NADH]m) and properties of shortening during continuous contractions. Old myocytes demonstrated decrements in mitochondrial NADH during continuous stimulation and exhibited impaired contractile function to workload and metabolic stress compared to young myocytes.

synapsesocial.com/papers/6a23b65755bd20cf6fa62367https://doi.org/10.14814/phy2.13485
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Also Consider

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