Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 6, 2026Open Veterinary JournalOpen Access

Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker in Experimental Tongue Squamous Cell Carcinoma Induced by 4-Nitroquinoline-1-Oxide—A Pilot Study

View Full Paper
Ask AI
Bookmark
Share

Authors

ABAkeem BamiroZIZul IsmailSSSharifah Sharif

Discussion

Loading...

Member takes

Overview

Pilot study evaluates NLR for short-term survival in rats with 4NQO-induced tongue cancer, suggesting significant prognostic value.

Key Points

  • This study aims to evaluate the prognostic performance of inflammatory biomarkers in a rat model of tongue squamous cell carcinoma induced by 4-nitroquinoline-1-oxide.
  • Female Sprague Dawley rats were exposed to 50 ppm 4NQO for 20 weeks.
  • Complete blood counts were performed to calculate NLR, PLR, and LMR before and after tumor induction.
  • Survival analysis was conducted using Kaplan-Meier curves and ROC analysis to assess NLR's predictive ability.
  • NLR showed good discrimination for predicting 42-day survival with an AUC of 0.901.
  • Optimal NLR cutoff identified at 0.5463, with sensitivity of 0.889.
  • Kaplan-Meier analysis revealed significantly poorer survival in rats with NLR > 0.55, log-rank P < 0.001.

Cite This Study

Bamiro et al. (2026) studied this question.

synapsesocial.com/papers/6a23b83e71a5da9775e74785https://doi.org/10.5455/ovj.2026.v16.i5.56
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic significance of neutrophil to lymphocyte ratio (NLR) in oral squamous cell carcinoma2024 · 8 citations
  2. 2Prognostic value of NLR versus PLR and LMR in patients with oral squamous cell carcinoma: a meta-analysis2026 · 3 citations
  3. 3Neutrophil‐to‐Lymphocyte Ratio as a Prognostic Factor of Survival Outcomes in Head and Neck Squamous Cell Carcinoma Receiving Neoadjuvant Immunotherapy2026
  4. 4Preoperative Inflammatory Blood Indices as Prognostic Markers in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis2026
  5. 5Neutrophil-Lymphocyte Ratio: Adjunct Prognostic Biomarker in Oral Squamous Cell Carcinoma (OSCC) – A Study in Delhi NCR2024