What does this research mean for the field?

Selectively removing short staple strands at the termini of asymmetrical right triangle DNA origami reduces vertex rigidity and suppresses aggregation driven by unbalanced arm twisting, thereby significantly improving placement fidelity and monomer yield. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore the aggregation mechanisms in asymmetrical DNA origami and enhance placement fidelity.

June 6, 2026JACS AuOpen Access

Suppression of Aggregation Enhances Placement Fidelity of Asymmetrical Right Triangle DNA Origami

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Authors

SZSuqing ZhouEast China Normal University YWYue WangShanghai Institute of Applied Physics DHDie HeShanghai Institute of Applied Physics

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Implication

Randomized trial reveals increased placement fidelity of asymmetrical DNA origami, suggesting structural tuning is crucial.

Key Points

This research aims to explore the aggregation mechanisms in asymmetrical DNA origami and enhance placement fidelity.
Investigated aggregation in asymmetrical right triangle DNA origami using atomic force microscopy.
Removed staple strands at vertex C to assess the impact on aggregation and placement fidelity.
Compared different modifications to evaluate their effectiveness in suppressing aggregation.
Optimized design improved monomer yield from 72 ± 1.1% to 87.3 ± 1.5%.
Placement fidelity enhanced from 33.1 ± 7.8% to 77.1 ± 4.8%.
Selective staple removal significantly decreased interorigami aggregation.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a23b8f271a5da9775e7505d https://doi.org/10.1021/jacsau.6c00423

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June 6, 2026JACS AuOpen Access

Suppression of Aggregation Enhances Placement Fidelity of Asymmetrical Right Triangle DNA Origami

View Full Paper

Ask AI

Bookmark

Authors

SZSuqing ZhouEast China Normal University YWYue WangShanghai Institute of Applied Physics DHDie HeShanghai Institute of Applied Physics

Discussion

Member takes

Implication

Randomized trial reveals increased placement fidelity of asymmetrical DNA origami, suggesting structural tuning is crucial.

Key Points

This research aims to explore the aggregation mechanisms in asymmetrical DNA origami and enhance placement fidelity.
Investigated aggregation in asymmetrical right triangle DNA origami using atomic force microscopy.
Removed staple strands at vertex C to assess the impact on aggregation and placement fidelity.
Compared different modifications to evaluate their effectiveness in suppressing aggregation.
Optimized design improved monomer yield from 72 ± 1.1% to 87.3 ± 1.5%.
Placement fidelity enhanced from 33.1 ± 7.8% to 77.1 ± 4.8%.
Selective staple removal significantly decreased interorigami aggregation.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a23b8f271a5da9775e7505d https://doi.org/10.1021/jacsau.6c00423

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