Passivating Blunt‐Ended Helices to Control Monodispersity and Multi‐Subunit Assembly of DNA Origami Structures

DNA Origami Structures DNA origami nanostructures tend to stick together due to blunt-end stacking of double-stranded DNA. This problem is commonly addressed by incorporating single-stranded DNA at the ends of the structures. In article number 2300441, Jonathan F. Berengut, Lawrence K. Lee, and co-workers explore the parameters and ramifications of these disordered domains and present an alternative strategy which incorporates orthogonal DNA domains to act as end-caps.