Randomized trial evaluates new topical therapy's effectiveness in patients with moderate to severe acne, suggesting improved outcomes and tolerability.
Key Points
Evaluate the effectiveness and tolerability of a retinol and salicylic acid delivery system in patients with moderate-severe acne.
40 Fitzpatrick skin type I-VI patients with moderate-to-severe acne evaluated over 12 weeks
Combination therapy using retinol and salicylic acid-targeted bio-delivery system
Multiple efficacy measures assessed including expert grading and microbiome analysis.
27.8% reduction in inflamed pustules at 2 weeks, 68.6% reduction at 12 weeks
61.1% improvement in acne nodules at 2 weeks, 92.2% by week 12
52% reduction in Cutibacterium acnes levels by week 12.