Editorial: Spatial and regional mapping of brain neural communication

based on functional connectivity network mapping (FCNM) and fMRI data from the Human Connectome Project to generate a system--level perspective linked to nodes within the frontoparietal and default mode networks (FPN, DMN, respectively). Wang et al. applied network mapping to understand heterogenous correlates of neuroticism that present as emotional instability and vulnerability and are often linked to the prefrontal cortex (PFC) and regional grey matter volume. By cross-modal associations between brain networks and neurotransmitter atlases their study highlights interconnected brain regions links to neuroticism. Key brain signaling networks include the DMN and Ventral attention network (VAN), highlighting the importance of VAN in neurotocism vulnerability, its potential as a therapeutic--target, and regional links to 5--HT2A, CBI and mGluR5. These studies demonstrate and refine brain region networks with functional outcomes in behavioral neuroticism, extraversion and adult onset dystonia taking advantage of global and regional neuroimaging maps, neurotransmitter atlases and computational modeling. The next critical steps will require microscaling of that regional information to understand neuron--neuron communication as well as spatial transcriptomics to generate information on genotype-connectome outcomes. The dynamic basis of neural communication and plasticity coupled across scales will be facilitated by development of expanded data resources and their interconnectivity via computational models and AI to bring synergistic advances in linked to behavior, aging and disease.